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I David Goldman Selected Research

Proton-Coupled Folate Transporter

1/2021Structural basis of antifolate recognition and transport by PCFT.
11/2020A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
1/2018Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.
1/2018Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1.
1/2017The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.
1/2014The intestinal absorption of folates.
7/2013Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.
9/2012Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
5/2012A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
10/2011Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico.
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I David Goldman Research Topics

Disease

21Hereditary Folate Malabsorption
11/2020 - 12/2006
19Neoplasms (Cancer)
01/2021 - 11/2002
6Mesothelioma
04/2008 - 11/2002
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2008 - 02/2006
3Leukemia
01/2005 - 06/2002
2Megaloblastic Anemia
04/2013 - 06/2002
2Breast Neoplasms (Breast Cancer)
02/2005 - 08/2003
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
09/2013
1biotin-responsive Basal ganglia disease
04/2013
1Ataxia Telangiectasia (Louis Bar Syndrome)
04/2008
1Colonic Neoplasms (Colon Cancer)
02/2006
1Hepatocellular Carcinoma (Hepatoma)
08/2005

Drug/Important Bio-Agent (IBA)

24Folic Acid (Vitamin M)FDA LinkGeneric
01/2021 - 11/2002
19Proton-Coupled Folate TransporterIBA
01/2021 - 09/2008
16Folic Acid AntagonistsIBA
01/2021 - 11/2002
14Pemetrexed (MTA)FDA Link
01/2018 - 11/2002
7Reduced Folate Carrier ProteinIBA
03/2007 - 11/2002
4Leucovorin (Folinic Acid)FDA Link
05/2014 - 04/2003
3Proteins (Proteins, Gene)FDA Link
11/2020 - 08/2003
3Methotrexate (Mexate)FDA LinkGeneric
05/2014 - 01/2004
310-propargyl-10-deazaaminopterinFDA Link
05/2014 - 09/2013
2Folic Acid TransportersIBA
04/2013 - 12/2010
2Thiamine (Aneurin)FDA Link
04/2013 - 06/2002
2Pharmaceutical PreparationsIBA
02/2005 - 01/2004
1Aspartic Acid (Aspartate)FDA Link
12/2010
1Glutamine (L-Glutamine)FDA Link
11/2010
1Caffeine (No Doz)FDA LinkGeneric
04/2008
1Trimetrexate (JB11)FDA Link
07/2007
1Erlotinib Hydrochloride (CP 358,774)FDA Link
06/2007
1Protons (Proton)IBA
12/2006
1PurinesIBA
10/2006
11- (9- deazaadenin- 9- yl)methyl- 3- hydroxy- 4- methylthiomethylpyrrolidineIBA
10/2006
1AdenineFDA LinkGeneric
10/2006
15'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA
10/2006
1ThymidineIBA
02/2005
1Ligases (Synthetase)IBA
04/2003
1GTP-Binding Proteins (G-Protein)IBA
11/2002
1Thymidine Monophosphate (TMP)IBA
06/2002
1Thiamine MonophosphateIBA
06/2002

Therapy/Procedure

1Therapeutics
01/2015
1Drug Therapy (Chemotherapy)
06/2012